Anabolic Steroids: A Practical GuideAndrogenic-anabolic steroids AAS are synthetic derivatives of the male hormone testosterone. They can exert strong effects on the human body that may be beneficial for athletic performance. A review of the literature revealed that most laboratory studies did not androgenic anabolic steroids dosage the actual doses of AAS currently abused in the field. Therefore, those androgenic anabolic steroids dosage may not reflect the actual adverse effects of clen with hgh. The available sterlids literature describes that short-term administration of these drugs by athletes can increase strength and bodyweight.
Anabolic Steroids Types, Side Effects, Examples, Dosing & Abuse
The different molecular configurations of the various anabolic steroids cause significantly different responses, and even a subtle change of one atom can elicit a unique response for a specific steroid. Oral steroids may cause liver toxicity which manifests as increases in liver function tests in the blood.
Patricia Salvato from Houston has found that common injectable steroids have not caused this kind of liver burden in over of her patients using anabolic steroids. Some people prefer injectables to oral steroids for this reason. Injectable steroids, however, may appear to cause elevated liver function tests during increased exercise and other stress in the body. Liver test elevations usually reverse with cessation of the steroids.
The forms of injectable testosterone available in the U. Without the cypionate or enanthate "carriers," testosterone is cycled through the body in several hours, so these carriers are important for ease of use, as they allow weekly rather than several times per day administrations. The first controlled study on high dose testosterone enanthate with normal HIV negative men was published in the New England Journal of Medicine on July 4, This study involved the use of mg per week of testosterone enanthate for ten weeks, and was controlled for weight training.
Four different combinations were evaluated; testesterone with exercise, testosterone without exercise, exercise without testosterone and no exercise with no testosterone. Those who were given testosterone plus exercise had the greatest increase in muscle strength and greater increases in body weight compared to the other groups.
The decanoate "carrier" delivers nandrolone over a slightly longer period of time than a cypionate carrier, but weekly injections are still preferred. The package insert administration recommendations of the manufacturers of nandrolone decanoate have recently been changed from bi-weekly injections to weekly injections.
Nandrolone does not produce as much androgenic activity in the body as testosterone, so there is considerably less potential for hair loss or prostatitis inflammation of the prostate. Julian Gold in Australia published two studies in and showing that mg of nandrolone decanoate produced significant increases in lean body mass and quality of life for HIV positive male patients.
Gary Bucher of Chicago's Center for Special Immunology, presented the first placebo controlled study of the anabolic steroid nandrolone decanoate with 73 HIV patients over 12 weeks. There was a significant increase in lean body mass, even though there was no specific weight training protocol, and we know that steroids exert their greatest effect on gaining LBM when weight training is performed. There are several points that should be noted.
First, the dosage used in this study is rather low at mg of nandrolone decanoate per week. Fred Sattler, is using milligrams of nandrolone per week. This higher dose is being studied because there is good reason to believe that it will be much more effective for increasing lean body mass yet still be safe.
There are several other studies in progress using these higher dose. Stanozolol is an unusual compound that is considered to be relatively free from side effects, even for women, because like oxandrolone, it has a very low androgenic potential. While the previously mentioned study on HIV-positive men using stanozolol showed significant bodyweight improvements from doses as low as 6 and 12 milligrams per day, anecdotal information suggests that stanozolol exerts its greatest effects when combined with anabolic steroids like nandrolone or testosterone.
Stanozolol, for unknown reasons, also appears to have a positive effect on libido, and much more so than oxandrolone. Watch for liver enzyme increases if taking protease inhibitors and stanozolol. Oxandrolone is also very mild and, according to the manufacturer, not liver toxic. However, there have been reports of people on ritonavir or other protease inhibitors who have experienced increases in their liver enzymes, which made them stop taking oxandrolone. Oxandrolone does not virilize women in low to moderate doses and it has been used in children also.
It is an expensive drug, and the manufacturer has created an expanded use program which is probably the most accessible in the AIDS industry.
CRIA is participating in a multicenter study of oxandrolone for women with unintentional weight loss and recently completed a similar study in men. It used to be called the "gorilla" steroid by bodybuilders in the 's. A study published in in the British Journal of Nutrition showed that this powerful oral anabolic steroid improves body weight with what appeared to be no significant side effects in HIV-positive men and women.
Oxymetholone was given for thirty weeks at a dose of mg per day. Weight gain averaged Notably, even the subset of patients burdened with AIDS-related infections continued to gain weight on oxymetholone. While oxymetholone is considered to be a harsh steroid with a high potential for side-effects, the subjects were reported to have no significant problems with liver function, water retention, virilization, and several side-effects thought to be associated with its use.
The dose was three times what many bodybuilders would use and the treatment period was considerably longer. Since oxymetholone was brought back to the U.
Resistance exercise with weights and machines has been shown to increase muscle hypertrophy growth with or without the use of anabolic steroids. As preciously mentioned, Dr. Shalender Bhasin in Los Angeles determined that HIV negative men receiving injections of mg per week of testosterone and who exercised with weights had more LBM gains than those receiving testosterone but no exercise. Marc Hellerstein in San Francisco just finished a controlled study using oxandrolone and exercise in HIV positive men.
He also found that men who exercised and took oxandrolone were the best responders to therapy. All exercises should be performed to one's best ability to finish repetitions in 3 sets per body part.
The most common and effective exercises are: Working out with a partner and keeping a workout logbook are also great ways to ensure success. Without proper nutrition and exercise, this therapy is only marginal in its effectiveness. Anyone who is considering the use of this therapy should become knowledgeable and empowered with information about these compounds, and the optimal nutritional and exercise programs.
Facebook , Twitter , RSS. All Rights Reserved The Body: The Body is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through The Body should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider. For those who need to regain their lost lean body mass LBM , anabolic steroids are a possible answer.
These compounds are being prescribed increasingly by some physicians to treat their HIV-infected patients. Many of them were originally synthesized in the 's and 40's in an effort to deliver a more optimal protein tissue building anabolic effect with less of the potential for masculinizing androgenic side-effects that are characteristic of testosterone itself.
Although they are not part of the "standard of care" for HIV disease, anabolic steroids have gained acceptance in reversing the loss of LBM, strength, sexual function, appetite, and general sense of well being in HIV positive patients. However, they have received a lot of bad press due to their abuse in the bodybuilding and sports world and were banned for general public use with the Anabolic Steroid Control Act enacted by the U.
This act made anabolic steroids Class III regulated drugs, available by prescription only to people with justifiable health problems. All anabolic steroids but one have been approved to treat anemia related to renal insufficiency and other non-wasting related disorders. So physicians who prescribe these compounds to treat LBM loss are doing so under an "off-label," yet legal, application. Women and Children Often Forgotten Women and children are often ignored when it comes to wasting.
Physicians may be afraid to prescribe anabolics to women because of the potential to masculinize them. Women also have the added pressure from society and sometimes their physicians to be thin, so wasting may go unreported and untreated in this population.
Most anabolics will stunt growth in children children with HIV also have slow growth problems. However, they are both very expensive, so many HIV-positive people have to turn to pharmaceutical compassionate use programs, which can be difficult to access.
How do Anabolics Work? The anabolic effect of anabolic steroids is elicited by the action of the steroid on androgen receptors in muscle tissue. The steroid binds to the receptor and is carried to the nucleus of the cell where it instructs the cell to increase protein synthesis.
This results in hypertrophy growth of the cells and the muscle tissue itself. How Discrimination Feeds Cigarette Use. A Response and Some Lingering Questions. Transgender Representation is Important. The Evolution of Antiretroviral Therapy: Past, Present, and Future. Fired Up and Ready to Vote: Butt Wait, There's More.
Advertisement Potential Side-Effects Testosterone, being the most androgenic of all compounds soon to be discussed, is responsible for most of the side effects cited in the literature. Other anabolic compounds are more benign than testosterone and still very effective in their anabolic action.
Can be obtained overseas. Slight chance of virilizing for women. Slight chance of virilization for women. Patients on protease inhibitors should watch liver function. Women report water retention. Balding in men, high blood pressure, water tetention, body hair growth in women and breast enlargement in men. Water retention, balding in men, acne, breast enlargement in men, may virilize women.
Any individual considering using anabolic steriods should consult their physician. Generally speaking, the less androgenic a steroid is, the fewer side effects there will be. The upper dosage listed for women is usually for severe wasting only. Women's systems do not tolerate anabolic steroids as well as men in general; caution is advised, and high dose is usually reserved for severe wasting. Struggling With Crystal Meth? Medication and Health Reminders.