11β-Hydroxysteroid dehydrogenaseIn these tissues, HSD11B1 reduces cortisone to the active hormone clenbuterol in usa that activates glucocorticoid receptors. The protein encoded by this 11b hydroxysteroid is a microsomal enzyme that 11b hydroxysteroid the conversion of the stress 11b hydroxysteroid cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone 11b hydroxysteroid cortisol. Too much cortisol can lead to central obesityand a particular variation in this gene has been associated with obesity 11b hydroxysteroid insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene. Moreover, 18alpha- glycyrrhizic acid from the root of glycyrrhiza 11b hydroxysteroid was discovered as an inhibitor.
Beta hydroxysteroid dehydrogenase - an overview | ScienceDirect Topics
The systematic name of this enzyme class is 11beta-hydroxysteroid: This enzyme participates in c steroid hormone metabolism and androgen and estrogen metabolism. Cortisol , a glucocorticoid, binds the glucocorticoid receptor. However, because of its molecular similarity to aldosterone it is also capable of binding the mineralcorticoid receptor. Both aldosterone and cortisol have a similar affinity for the mineralocorticoid receptor; however, there is vastly more cortisol in circulation than aldosterone.
In humans, there are two HSD11B isoforms: Inhibition of HSD11B1 has been suggested as a possible therapy for treatment of obesity and metabolic syndrome. From Wikipedia, the free encyclopedia. Not to be confused with Steroid beta-hydroxylase. The pathogenetic role of cortisol in the metabolic syndrome: The Journal of Clinical Endocrinology and Metabolism. D-lactate dehydrogenase cytochrome D-lactate dehydrogenase cytochrome c Mannitol dehydrogenase cytochrome. Glucose oxidase L-gulonolactone oxidase Xanthine oxidase.
Vitamin K epoxide reductase Vitamin-K-epoxide reductase warfarin-insensitive. Malate dehydrogenase quinone Quinoprotein glucose dehydrogenase. Mevalonate kinase Phosphomevalonate kinase Pyrophosphomevalonate decarboxylase Isopentenyl-diphosphate delta isomerase. Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase. Allosteric regulation Cooperativity Enzyme inhibitor.
Expressed in aldosterone -selective tissues, including kidneys, liver, lungs, colon, salivary glands, HSD2 neurons and placenta. In these tissues, HSD11B2 oxidizes cortisol to cortisone and prevents illicit activation of the mineralocorticoid receptor. To lanosterol Farnesyl-diphosphate farnesyltransferase Squalene monooxygenase Lanosterol synthase. To pregnenolone Cholesterol side-chain cleavage.