Some parents are using CBD oil to treat seizures, pain, and even autism in Its popularity is growing as a remedy for issues like chronic pain, anxiety, and . Everything You Need to Know About Heavy Metals and Contaminants in Baby Food. Are you wondering if your kids should be taking CBD oil? What does that mean right now if you have a child with anxiety or another disorder. The use of CBD oil (cannabidiol, extracted from marijuana) for kids is growing in popularity. We've Getty Images . CBD oil can be highly effective in treating seizures, autism, ADHD, depression, and anxiety in children.
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Its popularity is growing as a remedy for issues like chronic pain, anxiety, and side effects from cancer treatments. Some parents even say giving their child the oil has helped with autism and seizure disorders. But is trying it wise—or even legal? Though it's derived from cannabis, CBD oil is not the same as recreational marijuana or medical marijuana and doesn't contain meaningful amounts of THC, the compound in marijuana that produces a "high".
The oil, which is not physically addictive, is typically taken as a liquid under the tongue, via gel capsule, or as a cream. It can also be mixed with food.
CBD is thought to work on something in the body called the endocannabinoid system, which is involved in maintaining homeostasis, or balance. There are receptors for this system in many parts of the body, including the brain, which is why it's believed to help a host of different conditions.
The most research done on CBD is for its use with seizure disorders like epilepsy. For other conditions, the evidence is largely anecdotal. Recent studies have found CBD to significantly reduce the frequency of seizures in children and teens.
Here are a few to check out:. We previously detailed how CBD reduces seizures, and you can learn more about how it works here. In cases where a deficiency in naturally-produced cannabinoids occurs, supplementing with plant-derived cannabinoids like CBD may be beneficial. Learn more about the safety considerations of giving children CBD here.
CBD is available in various products that are convenient for children to use. Pure CBD hemp oil, as well as tinctures and liquid concentrates, can be held under the tongue and absorbed by the mucus membranes in the mouth before swallowing. If children are unable to hold the CBD oil in their mouth, it can also be ingested.
Learn more about the various CBD consumption methods here. CBD oil that is derived from hemp is legal under federal law in the U. The American Academy of Neurology conducted a systematic review in which included 34 studies that used medical marijuana to treat MS, epilepsy, and movement disorders.
Despite this, parents and patients are making the decision to use these products for 3 reasons according to Cilio et al: It is important to note that the following studies are based on parental perceptions and thus we cannot draw definitive conclusions.
She suffered from frequent status epilepticus. Charlotte failed multiple medications, and at 5 years of age, she had significant cognitive delay and required help with all of her activities of daily living. Stories like Charlotte's have prompted parents across the country in similar situations to move their families across the country to gain access to these products.
Investigators at Stanford University administered a survey to parents on Facebook to identify parentally reported effects of CBD on their child's seizures. Twelve of these 19 patients were also able to be weaned from another antiepileptic drug. In addition, parents reported overall better mood, increased alertness, and better sleep.
Parents reported oral CBD dosages of 0. As with previous surveys, dosage and formulations were varied but based on parental report of formulation used. Overall, most parents As mentioned above, these surveys should be evaluated carefully given the inability to verify dose, formulation, and response.
The conclusion that can be made is that there is a rather strong positive parental perception regarding the efficacy of cannabinoids, specifically CBD. Most orphan drug designations for CBD are for pediatric seizure disorders Table 4. Published findings from open-label use of CBD for treatment-resistant epilepsy under an expanded-access program at 11 epilepsy centers in the United States suggest that CBD might reduce seizure frequency and might have an adequate safety profile in children and young adults with this condition.
After announcing positive results from 2 pivotal randomized, double-blind, Phase 3 trials for the treatment of seizures related to LGS, and a third for seizures associated with Dravet syndrome in , GW Pharmaceuticals expects to submit a single New Drug Application for both indications to the FDA in the first half of for its proprietary pharmaceutical-grade CBD product Epidiolex. Cannabinoids and CBD use in this patient population is a growing interest on social media sites.
While the data for these indications are limited to case reports using dronabinol, some of the benefits of CBD on behavior and motor skills reported in the aforementioned retrospective studies in epilepsy may be transferable to this population as well. A 6-year-old patient with early infant autism received enteral dronabinol drops titrated up to 3.
He had improvements in hyperactivity, irritability, lethargy, stereotype, and speech. The dronabinol dose ranged from 2. Seven of the 10 patients had significant improvement in their self-injurious behavior that lasted through the follow-up at 6 months.
Two of the 10 patients experienced agitation and the drug was discontinued. Perinatal brain injury can be induced by neonatal asphyxia, stroke-induced focal ischemia, and neonatal hypoxia-ischemic encephalopathy, among other things. These conditions lead to long-lasting functional impairment due to neuroinflammation, apoptotic-necrotic cell death, and brain lesions. The endocannabinoid system responds early to neuronal damage, working to prevent glutamate excitotoxicity and regulate the inflammatory response.
While there are no current human studies, results from mice and pig models demonstrate that CBD can reduce the density of necrotic neurons and modulate cytokine release. Most recently, researchers have reported on the use of CBD in both in vitro and in vivo animal studies of neuroblastoma NBL , a common childhood cancer. Worldwide, marijuana is the most commonly abused illegal substance and adolescent daily use is on the rise. Unfortunately, the neurocognitive and behavioral effects of marijuana use in pediatric patients, including its effects on psychological dysfunction, amotivation syndrome, and carcinogenic risk, have been widely reported.
Evolving legislation and the increased use of cannabinoid products outside of investigational studies have also impacted our health care delivery and emergency resources.
The state of Colorado has been on the forefront of the medicinal and recreational use of cannabis debate. Wang et al 48 reported the occurrences of pediatric emergency department visits associated with marijuana exposure before and after changes in drug enforcement in A total of patients younger than 12 years were evaluated for unintentional ingestions from January 1, , to December 31, Patients ranged in age from 8 months to 12 years and presented with symptoms of lethargy, ataxia, and respiratory insufficiency.
While the dosages were not reported, 7 patients ingested a marijuana edible. Eight of the 14 patients were admitted to the hospital with 2 admissions to the pediatric intensive care unit. Prior to diagnosis, these 14 patients received routine testing such as urinalyses, complete blood counts, and complete metabolic panels. Some of these patients also received more invasive testing including computed tomography, activated charcoal, lumbar punctures, and intravenous antibiotics.
All of these contribute to higher hospital and emergency room costs, increased lengths of stay, and potential harm to the patients. In addition to increased emergency room visits, from to , the call volume at Poison Control Centers for pediatric marijuana exposures had increased by None of these products are required to have safety packaging to prevent accidental ingestion by children.
In addition, no warning labels or verification of product ingredients is required, leaving the medical community caught between providing safe medical care and allowing patient autonomy. As mentioned previously, the AAP has published recommendations to limit the access of marijuana to children. In , amidst medical marijuana legalization in several states, Seamon et al 21 identified that pharmacists needed to be attentive to the legislative changes going on at the state and federal levels.
Pharmacists are uniquely poised to understand the medicinal chemistry as well as the practical implications associated with decriminalization and legalization. Pharmacists can continue to educate both medical professionals and lay people about the differences among cannabinoids, and help to remove the stigma around appropriate and legal use of CBD products.
At the same time, medical professionals need to remember the documented deleterious effects of acute marijuana intoxication on neurocognitive development and psychiatric issues.
Many health care facilities are working through processes that address patient use of these medications. Whatever the state and situation, pharmacists need to be aware of the external factors associated with allowing a patient to use CBD in an inpatient setting.
Pharmacists are also poised to participate in the design and evaluation of current and future research in this area. The importance of drug interactions between CBD and other antiepileptics remains uncertain both for the efficacy and safety of CBD products.
The difference in concentrations, dosages, and formulations of various products sold at private dispensaries is not standardized or regulated.
Differences in state legislation on allowable concentrations and amounts can be confusing for patients and their families, and pharmacists can help to provide that information. Various organizations have been helpful in updating and summarizing this information. Cannabis and its ingredients have had a fascinating history over the past years, but lack of published data precludes fully recommending its use for medicinal purposes in pediatrics. Further study is underway and will add to our knowledge of the efficacy and safety of CBD in pediatrics.
Long-term studies to assess neurocognitive development with CBD will need to be assessed as well. As pharmacists, it is our duty to provide our patients and their parents with the most accurate, safe, and legally appropriate advice. Disclosures The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria.
Of note, both Augusta University ClinicalTrials. National Center for Biotechnology Information , U. J Pediatr Pharmacol Ther. Author information Copyright and License information Disclaimer. Abstract Despite its controversial nature, the use of medical marijuana and cannabis-derived medicinal products grows more popular with each passing year. CBD, cannabidiol; cannabis; epilepsy; pediatrics; pharmacy.
Children and CBD
High levels of CBD and low levels of THC are found in most medical using CBD as a homeopathic remedy for pain relief, depression and CBD products contain dangerous chemicals or synthetic CBD oil. User Picture. silhouette image of an adult leading a child by the hand background marijuana leaves Years earlier, they had heard about treating seizures with CBD oil, . She's epileptic and everytime she gets anxiety she has seizures.”. Parents are looking for better options for treating seizure, anxiety, and cancer side effects in young children. Could CBD oil be the answer?.