CBD oil and cannabis plant. Researchers look to cannabidiol in the hope of improving survival rates for people with pancreatic cancer. A study published this week found that mice with pancreatic cancer survive “I put the paste into capsules with coconut oil and CBD oil. Cancer patients have reported finding relief from pain and stimulation of appetite from the use of marijuana, also known as cannabis. In fact.
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According to data from the National Cancer Institute NCI , in the United States, there will be an estimated 55, new cases of pancreatic cancer by the end of this year.
Treatments for this type of cancer include surgical resection the removal of tissue affected by the cancer , as well as chemotherapy. Unfortunately, the prognosis tends to be poor, with only an 8. Marco Falasca — of QMUL — and colleagues have conducted a study on a mouse model of pancreatic cancer, investigating an intriguing lead.
They wanted to see if administering cannabidiol CBD — a naturally occurring component of medical cannabis — alongside chemotherapy medication would improve prognosis following treatment. The research team's findings are now reported in the journal Oncogene. The researchers focused on the potential of CBD rather than another cannabis compound, tetrahydrocannabinol THC , because the former does not cause psychoactive effects.
This has led to CBD already gaining approval for use in a healthcare context. If further studies show that CBD is effective in improving cancer treatment, this could mean that doctors will be able to use it in cancer clinics immediately. In the current study, Prof. Falasca and team worked with a mouse model of pancreatic cancer, which they treated with CBD alongside a typical chemotherapy drug, called " Gemcitabine. The team found that, following this combination treatment, the rodents survived almost three times as long as mice from a control group, which had only been treated with Gemcitabine.
Falasca, adding, "We found that mice with pancreatic cancer survived nearly three times longer if a constituent of medicinal cannabis was added to their chemotherapy treatment. These results are very exciting for the researchers, who hope that, thanks to the fact that CBD is already considered safe, they will soon be able to use it in clinical trials testing this combination treatment in human patients.
The researchers also note that previous studies have shown that CBD can improve symptoms associated with chemotherapy treatments, including nausea, pain, and vomiting. If future clinical trials prove that CBD is effective in improving survival rates for individuals going through chemotherapy for pancreatic cancer, it could also mean that the cannabis compound will help to offset some of the treatment's side effects.
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Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Privacy Terms Ad policy Careers. This is nearly three times as long as the mice given the placebo, and around twice as long as the mice given CBD or chemotherapy alone.
As well as studying the survival rates of the mice, the GPR55 gene was also examined as it has previously been recorded as being involved in many of the cellular functions associated with cancer proliferation.
The gene produces proteins inside cell membranes that can act as detectors for various substances, including cannabinoids such as CBD.
Immunohistochemistry analysis showed an accumulation of GPR55 in human cancer cell lines compared to healthy human cell lines, which lends further weight to the notion that GPR55 may be involved in the proliferation of cancer cells.
This prevents the proteins from interacting synergistically with other compounds to promote the proliferation of pancreatic cancer cells. As a result, this inhibition of the GPR55 signaling pathway slows the growth and multiplication of these typically aggressive cancer cells. In the past, there have been recorded cases of cell lines developing a resistance to gemcitabine treatment. As gemcitabine is one of the most common chemotherapy drugs prescribed for pancreatic cancers, the potential for pancreatic cancer cells building up a resistance to the drug is highly concerning.
In the interest of combatting this, the researchers in this study also examined the effects of CBD on activation pathways that are thought to be associated with gemcitabine resistance, such as increased ERK activity.
The team found that CBD was able to decrease ERK activity , and as a result, could hinder at least one of the potential pathways to chemotherapy resistance. As well as the increased life expectancy and decreased drug resistance, Professor Marco Falasca, the corresponding author on the research project, also emphasized additional benefits to using CBD in conjunction with traditional chemotherapy drugs. If we can reproduce these effects in humans, cannabidiol could be in use in cancer clinics almost immediately, compared to having to wait for authorities to approve a new drug.
The Effect of Cannabidiol Treatment on Life Expectancy The team studied pancreatic cell cultures as well as mice that had been genetically modified to develop pancreatic cancer. GPR55 Signaling and Cancer Proliferation As well as studying the survival rates of the mice, the GPR55 gene was also examined as it has previously been recorded as being involved in many of the cellular functions associated with cancer proliferation.
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Keywords: pancreatic cancer, cannabinoids, pain, survival .. Cerny T. Comparison of orally administered cannabis extract and delta tetrahydrocannabinol in. Cannabidiol (CBD) and other CBD-containing cannabis products have already Pancreatic cancer is the 11th most common cancer diagnosis. Substance in cannabis 'could boost pancreatic cancer treatments' by cannabis oil, which contains both CBD and tetrahydrocannabinol (THC).