Phytocannabinoids are cannabinoids that occur naturally in the cannabis plant. These cannabinoids are abundant in the viscous resin that is produced by glandular structures in the cannabis plant called trichomes. Other common cannabinoids include cannabidiol (CBD) and cannabinol. Surg Neurol Int. Apr 26; doi: /rodance.info_45_ eCollection Review of the neurological benefits of phytocannabinoids. Maroon J(1), Bost. It is intriguing that during human cultural evolution man has detected plant natural products that appear to target key protein receptors of important physiological.
Phytocannabinoids are a key chemical component in the cannabis plant. The cannabis plant contains compounds that have been identified by researchers, out of those compounds are considered phytocannabinoids. Different strains of cannabis contain varying levels of the different phytocannabinoids. Growers frequently cultivate marijuana plants to contain higher or lower levels of such cannabinoids, especially THC and CBD. Phytocannabinoids are, for the most part, insoluble in water but are soluble in alcohols, fats, and other non-polar organic solvents.
Definition - What does Phytocannabinoids mean? MaximumYield explains Phytocannabinoids Because of the cannabis plant's unique phytocannabinoids, the use of medicinal marijuana has become commonplace in many areas of the world as an acceptable treatment for numerous diseases and disorders.
Breeding with Autoflowering Cannabis. Multiple sclerosis CBD and deltaTHC MS is an autoimmune disease that promotes demyelination of neurons and subsequent aberrant neuronal firing that contributes to spasticity and neuropathic pain. Use of cannabis-based medicine for neurodegenerative conditions The use of cannabis-based medicine for the treatment of MS has a long history and its interaction with the ECS shares many of the same pathways of other neurodegenerative conditions.
American Academy of Neurology statement on medical marijuana In , the American Academy of Neurology AAN published a review article of 34 studies investigating the use of medical marijuana as extracts, whole plants and synthetic phytocannabinoids for possible neurological clinical benefits.
MS animal models utilizing deltaTHC MS animal models using autoimmune encephalomyelitis EAE have been used that demonstrate demyelination, neuroinflammation, and neurological dysfunction associated with infiltration of immune cells into the CNS consistent with the human disease.
Neuropsychiatric and brain trauma Cannabidiol CBD is recognized as a nonpsychoactive phytocannabinoid. Antidepressant and neuroprotective properties Antidepressants, used for the treatment of depression and some anxiety disorders, also possess numerous neuroprotective properties, such as preventing the formation of amyloid plaques, elevation of BDNF levels, reduction of microglia activation, and decreased levels of proinflammatory mediators.
Rat models; efficacy of CBD in neurobehavioral disorders In rat models of neurobehavioral disorders, CBD demonstrated attenuation of acute autonomic responses evoked by stress, inducing anxiolytic and antidepressive effects by activating 5HT1A receptors in a similar manner as the pharmaceutical buspirone that is approved for relieving anxiety and depression in humans.
Human imaging studies correlated with CBD Human imaging studies have demonstrated CBD affects brain areas involved in the neurobiology of psychiatric disorders. Tetrahydrocannabinol Interestingly, THC, administered prior to a traumatic insult in human case studies and animal models has had measurable neuroprotective effects.
Utility for glioblastoma multiforme Glioblastoma multiforme GBM is the most frequent class of malignant primary brain tumors. CBD reduces growth different tumor xenografts CBD has also been shown to reduce the growth of different types of tumor xenografts including gliomas. Intractable epilepsy Cannabidiol Reports of cannabis use in the treatment of epilepsy appear as far back as BC. CBDs reduce neuronal hyperactivity in epilepsy CBD's overall effect appears to result in reduction of neuronal hyperactivity in epilepsy.
Endogenous cannabinoids Endogenous cannabinoids appear to affect the initiation, propagation, and spread of seizures. Safety A comprehensive safety and side effect review of CBD in on both animal and human studies described an excellent safety profile of CBD in humans at a wide variety of doses.
CBD — better safety profile vs. Adverse effects The AAN review of 34 articles on MS using cannabinoids of various forms noted several adverse effects. Prescribing medical marijuana Ultimately, prescribing medical marijuana either as a primary treatment or adjunctive therapy will require extreme care and knowledge about the patient's goals and expectations for treatment.
Have you counseled the patient documented by the patient's signed informed consent regarding the medical risks of the use of marijuana—medical, psychological, and social such as impairment of driving or work skills and habituation? Does your patient have a history of misused marijuana or other psychoactive, addictive prescription and illegal drugs? Will you know the standardization and potency content of the medical marijuana to be used and whether it is free of contaminants?
Legalization of marijuana in many states: Need for education Because of the rapid legalization of medical marijuana by the majority of state legislatures in the U.
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Intro to Phytocannabinoids
A cannabinoid is one of a class of diverse chemical compounds that acts on cannabinoid . Phytocannabinoids are known to occur in several plant species besides cannabis. These include Echinacea purpurea, Echinacea angustifolia. Phytocannabinoids are the naturally occurring cannabinoids found in the cannabis plant. This is opposed to synthetic cannabinoids that are manufactured . It might interest you to know that there's actually a minimal difference between phytocannabinoids and cannabinoids.