Cannabidiol (CBD) is a non-psychoactive phytocannabinoid that has reportedly helped a number of people with a variety of symptoms and. How To Use CBD Oil: Why I'm Now Using % Legal Cannabis For now, and take a side-track to go peruse the more than 20, articles published in peer. CBD is typically extracted from the cannabis plant as an oil or a powder. There is also a vast number of different products and brands on the market. If the concentration of CBD is not listed, use the following formula to help guide your.
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The mechanism of action of CBD is multifold. CB 1 and CB 2 receptors. The CB 1 receptors are located mainly in the brain and modulate neurotransmitter release in a manner that 1 prevents excessive neuronal activity, thus calming and decreasing anxiety; 2 reduces pain; 3 decreases inflammation; 4 regulates movement and posture control; and 5 controls sensory perception, memory, and cognitive function.
Anandamide, an endogenous ligand that occurs naturally within our bodies, binds to the CB 1 receptors through the G-protein coupling system. CBD has an indirect effect on the CB 1 receptors by stopping the enzymatic breakdown of anandamide, allowing it to stay in the system longer and to provide its medical benefits. The CBD helps to mediate the release of cytokines from the immune cells in a manner that helps to reduce inflammation and pain.
Other mechanisms of action of CBD include stimulation of vanilloid pain receptors, such as the transient receptor potential cation channel subfamily V member 1 TRPV-1 receptor, which are known to mediate pain perception, inflammation, and body temperature.
Since the s, a considerable number of published articles have addressed the chemistry, biochemistry, pharmacology, and clinical effects of CBD. Although studies have demonstrated the calming, anti-inflammatory, and relaxing effects of CBD, clinical data demonstrating the use of CBD to obtain help in marijuana withdrawal is minimal. One prior case study by Crippa et al 16 documented the positive effects of using CBD for the treatment of marijuana withdrawal. The current case study offers further evidence that CBD is effective as a safe method of transitioning off marijuana without unwanted side effects.
The patient was a year-old male who presented with a long-standing diagnosis of bipolar disorder and a daily addiction to marijuana. His presenting concerns included erratic behaviors, anxiety, inconsistent sleep patterns, and irritability. He currently lives with his parents, works as a self-employed driver, and teaches chess to children. Informed consent was received from the patient.
Evaluations included 1 a basic, complete blood count; 2 a nutritional evaluation; 3 a comprehensive metabolic panel; 4 a lipid panel; 5 a measurement of methylene tetrahydrofolate reductase MTHFR ; 6 a celiac panel; 7 a measurement of thyroid function; 8 a measurement of iron levels; and 9 a quantitative electroencephalogram qEEG.
Dietary recommendations were then implemented as was a regimen of nutritional supplements. The patient also received neurofeedback sessions and bodywork. Prior to the period of the case study, he had been stable for a number of years. In May , it was recommended that he begin taking CBD as a way of transitioning off the daily marijuana use and stabilizing his erratic moods.
The dosage was gradually decreased from 24 to 18 mg, with the patient using no sprays during the day and 6 sprays at bedtime. CannaVest Company Las Vegas. NV, USA , which had no involvement in the case study or distribution of the product, provided the CBD oil that was administered to the patient. The PSQI is a standardized and validated self-report instrument that measures sleep quality over the prior month.
Low scores indicate better sleep. A score under 5 means that you have no sleep concerns. The HAM-A scale is a standardized and validated measure of anxiety in an adult population that has been in active use for decades. A score of 17 or less indicates mild anxiety in terms of severity. A score from 18 to 24 demonstrates mild to moderate anxiety severity. Last, a score of 25 to 30 indicates moderate to severe anxiety. Using the CBD oil, the patient was able to maintain nonuse of marijuana.
With a subsequent, gradual decrease in anxiety, the patient was able to maintain a regular sleeping schedule Table 2. He was able to get a more secure job as a self-employed driver, and he continued to teach chess to children.
He also became more interactive with his family and friends. The current case study found that CBD oil can be an effective compound to use for transitioning an individual off addictive use of marijuana. However, the patient made significant gains in taking responsible actions and presented fewer erratic and disorganized behaviors. A systematic review of the literature previously had examined 14 studies on the use of CBD oil to modulate various neuronal circuits involved in drug addiction.
One reported consequence of the cessation of daily marijuana use is a withdrawal syndrome that is characterized by irritability, anxiety, marijuana craving, decreased quality and quantity of sleep, and reduced food intake. The patient reported being less anxious and sleeping better since taking the CBD oil.
He reported not using any marijuana since starting the CBD and was proud of his accomplishment of getting a job as a self-employed driver and continuing with teaching chess to children. The author participated in no competing interests that would have affected the results of the case study.
No financial support was provided by CannaVest at any time. National Center for Biotechnology Information , U. Journal List Integr Med Encinitas v. Author information Copyright and License information Disclaimer. Scott Shannon, md , is a psychiatrist; and Janet Opila-Lehman, nd , is a naturopathic physician. Scott Shannon, md , E-mail address: Abstract This case study illustrates the use of cannabidiol CBD oil to decrease the addictive use of marijuana and provide anxiolytic and sleep benefits.
Presenting Concerns The patient was a year-old male who presented with a long-standing diagnosis of bipolar disorder and a daily addiction to marijuana. Open in a separate window. Hamilton Anxiety Rating Scale The HAM-A scale is a standardized and validated measure of anxiety in an adult population that has been in active use for decades. Results Using the CBD oil, the patient was able to maintain nonuse of marijuana.
Table 2 Patient Sleep. Discussion The current case study found that CBD oil can be an effective compound to use for transitioning an individual off addictive use of marijuana. Patient Perspective The patient reported being less anxious and sleeping better since taking the CBD oil.
Footnotes Author Disclosure Statement The author participated in no competing interests that would have affected the results of the case study. Cannabidiol interferes with the effects of delta 9-tetrahydrocannabinol in man. Influence of cannabidiol on delta 9-tetrahydrocannabinol effects.
Multiple mechanism involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. There are many ways in which CBD can be incorporated into daily life, the following article will highlight some of the most popular ways of using CBD for medicinal purposes. Microdosing with CBD You may have heard the saying; a little goes a long way. Microdosing is a trend that has been on the horizon for a while now, and it looks set to stay.
How is it done? Typically speaking, a micro-dosage is 2. Research performed on rodents suggests that CBD can reduce inflammation in the body. Microdosing introduces CBD into the body in very small amounts according to a semi-regular schedule. Topical CBD creams While many people think of oral ingestion when it comes to CBD oil, topical creams containing CBD can be equally beneficial and are believed to have excellent pain-relieving and anti-inflammatory action.
These creams are also used by those suffering from arthritic symptoms. According to this study , CBD could relieve painful arthritic symptoms without the negative side effects that sometimes accompany the use of pharmaceutical drugs. The study reports that by using a topical cannabis oil cream, the metabolic system is bypassed thereby increasing absorption, assimilation, and efficiency of CBD. Infusing food with CBD can be both enjoyable and effective. However, those dealing with an acute condition that needs immediate relief would be best to consider a more direct method of ingestion due to the reduced bioavailability of the CBD product: The vapor is then inhaled by the user.
CBD oil for vaporizers can be obtained in cartridges or refill bottles, and both are easily found across most of the U. How does vaping CBD oil feel? Due to a lack of scientific studies on the area of vaping CBD, the information is limited to anecdotal reports. The inhalation of the vapor into the lungs allows for fast delivery into the bloodstream since it does not first pass through the metabolic system, therefore anecdotal reports state that vaping CBD provides an almost instantaneous effect.
Using CBD oil as a daily supplement or as a treatment for a health condition is becoming increasingly popular.
How to Use CBD Oil Products
Products marketed as CBD oil may contain THC. It's thought Some research indicates that the use of CBD oil may trigger a number of side effects, including. Products like CBD oil, also known as cannabis oil or cannabidiol, have the Home Office granted a day-licence for the use of the banned. Only one purported use for cannabidiol, to treat epilepsy, has significant Worse , about 1 in 5 CBD products contained the intoxicating pot.