Migraines can often be treated with Excedrin, but now people are using cannabis to combat their pain. Find out why, and how they compare. Excedrin Migraine Pain Reliever and its generic counterparts contain the excedrin-migraine excedrin-extra-strength excedrin-comparison of boiling water over the stove, carefully lean over the pot and inhale the steam. In this article I'm going to compare excedrin migraine which is one of But CBD oil and cannabis have been used for thousands of years for all.
vs Comparison Migraines Excedrin Cannabis - for
Although placebo-controlled clinical trials are still needed to appropriately determine efficacy, it appears likely that cannabis will emerge as a potential treatment for some headache sufferers. Cite this article as: National Center for Biotechnology Information , U. Journal List Cannabis Cannabinoid Res v. Published online Apr 1. Lochte , Alexander Beletsky , Nebiyou K.
Author information Copyright and License information Disclaimer. This article has been cited by other articles in PMC. Abstract Headache disorders are common, debilitating, and, in many cases, inadequately managed by existing treatments. Historical Use of Cannabis for Headache Historical reports, though not ideal forms of evidence, are important resources for understanding the potential use of cannabis in the treatment of headache disorders.
All patients experienced improvement, some were cured. Donovan 41 Migraine A: Usually lasting relief, sometimes curative. Greene 35 ; Russo 18 Clavus hystericus and migraine P: Waring 36 Migraine or sick headache P: Taken before each meal Women: Seguin cited in Russo 18 Migraine or sick headache A: Clinical experience Found to be the most effective drug for migraine.
Can abort attacks in some cases. Clinical experience Helpful prophylactically and abortively, even in cases of migraine refractory to other treatments. Mackenzie 38 Migraine P: Open in a separate window.
A, abortive; P, prophylactic. Clinical Studies on Cannabis Use for Headache The schedule 1 classification of marijuana in has made rigorous clinical studies on the treatment efficacy of this substance difficult. Subject population Type of study Significant findings Source 3 Chronic smokers Case series Migraines after cannabis cessation. Remission of headache with return to use in one patient. El-Mallakh 42 Patient with migraine Case report Women found superior relief of migraine with cannabis compared with beta-blockers, opiates, and ergots.
Petro cited in Russo 18 Patient with migraine Case report 18 years of treatment failure with standard pharmaceuticals, found success with smoked cannabis. Grinspoon and Bakalar 45 Patient with migraine Case report Successful treatment with cannabis that did not produce inebriation. Terwur cited in Russo 18 Patients prescribed cannabis for migraine Retrospective study Migraine occurrences decreased from In one case, cannabis improved response more than dronabinol.
In three cases, cannabis was used to abort headache in the prodromal phase. Mikuriya 48 Patients seeking physician recommendation for medical cannabis Survey Use as treatment unknown.
Cannabinoids and Headache Pathophysiology The pathophysiological mechanisms of many headache disorders are not entirely understood. Studies on the Role of Cannabinoids in Headache Pathogenesis. Mechanistic category Significant findings Source Systemic Variants in the cnr1 gene encodes for the CB1 receptor resulting in decreased expression of CB1 associated with migraine and trigeminovascular activation.
Could desensitize receptor and inhibit pathophysiological mechanism of headache. Underlying cause of headaches Various genetic factors can predispose individuals to migraines. Glutamate signaling One of the first subjective indicators of a migraine is the occurrence of an aura, a perceptual abnormality that often precedes a migraine attack. Trigeminovascular activation Another component of most headache disorders is overactivation of the trigeminovascular system, the primary sensory nerve tree for the head.
Platelet stabilization The hematological properties within the dilated cranial blood vessels themselves may also play an important role in the pathophysiology of migraine. Modulation of afferent nociceptive signals Endocannabinoids have a well-established role in the modulation of pain signals at the spinal level 81 and contribute to the descending modulation of pain through brainstem nuclei.
Discussion Headache disorders are common, painful, and disabling; moreover, treatment for these disorders is inadequate for many sufferers.
The development of dosing and treatment guidelines for the use of cannabis in the treatment of headache disorders. Physicians should consider discussing dosing strategies when recommending cannabis as headache treatment, with the aim of maximizing efficacy and minimizing harm.
A focus on dose consistency through the use of oral cannabinoids or metered-dose inhalers could benefit future clinical trials by allowing for easier blinding and placebo control. Moreover, the use of oral cannabinoids could have unique benefits in the prophylactic treatment of headache, because it could avoid concentration peaks and individual differences in bioavailability. Investigation of the anti-headache effect of cannabidiol CBD. This review found no available information on the use of CBD as a treatment for headache.
Nevertheless, CBD has shown efficacy for headache-related conditions i. Identification of variables that could predict treatment receptivity in headache patients. This could include stratification of headache disorders or patients based on sex, genetics, metabolic function, or neuronal biomarkers. Investigation of the long-term risks of cannabis treatment for headaches. This should aim at quantifying any side effects, withdrawal symptoms, dependence, refractory headaches, or negative outcomes from cannabis treatment for headaches.
Evaluation of other anti-headache drugs that target the endocannabinoid system. Evaluation of cannabis in combination treatment with analgesic or other anti-headache medications or as a second-line treatment in patients who are refractory to traditional medications.
Conclusion The present review examines the historical guidelines for cannabis treatment of headache, available clinical data on the use of cannabis for headache, and preclinical literature on the role of the endocannabinoid system in headache pathophysiology.
Author Disclosure Statement No competing financial interests exist. Burden of migraine in the United States: The global burden of headache: Migraine and tension-type headache in children and adolescents. Epidemiology of headache in a general population—a prevalence study. Hansen JM, Levy D. Headache Ashina M, editor; , Geppetti P, editor. The International Classification of Headache Disorders, 3rd edition.
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Dublin J Med Sci. Migraine headaches and drug abuse. Pharmacology, Toxicology, and Therapeutic Potential. New York, , pp. Grinspoon L, Bakalar JB. Marihuana, the forbidden medicine. Effects of medical marijuana on migraine headache frequency in an adult population.
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Nabilone for the treatment of medication overuse headache: Cluster attacks responsive to recreational cannabis and dronabinol. J Neurol Neurosurg Psychiatry. Use of cannabis among cluster headache sufferers. Are cannabis-based chemicals helpful in headache? The perceived effects of smoked cannabis on patients with multiple sclerosis.
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Inhaled cannabis for chronic neuropathic pain: Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: Cannabinoids for control of chemotherapy induced nausea and vomiting: Who are medical marijuana patients? Population characteristics from nine California assessment clinics. Prevalence of medical marijuana use in California, Medical marijuana in California, — The Journal of Cannabis in Clinical Practice.
Self-reported cannabis use characteristics, patterns and helpfulness among medical cannabis users. Am J Drug Alcohol Abuse. Adverse effects of cannabis on health: Prog Neuropsychopharmacology Biol Psychiatry. Treatment of cluster headache. A double-blind comparison of oxygen v air inhalation.
Dexanabinol HU in the treatment of severe closed head injury: Variations in the cannabinoid receptor 1 gene predispose to migraine. Endocannabinoids in chronic migraine: CSF findings suggest a system failure. During the first two trimesters of pregnancy there may be some exceptions which should be discussed with your doctor. In terms of using CBD during pregnancy and while breastfeeding, there is not enough information to make an informed decision and it should be discussed with your doctor.
That said studies done on cannabis and pregnancy are not conclusive either but it does show that small amounts are not particularly harmful. CBD may interact with blood thinning medications so it should be consulted with your doctor before use. CBD oil, because of its connection to cannabis has some illegality issues even if hemp might be legal. That said, CBD oil is more expensive because of the extraction process but may be starting to get covered by some insurance companies because of legalization.
My overall pick here is definitely CBD because of its amazing effect on supporting the endocannabinoid system and actually providing nutrients along with all of its benefits which can help our brains deal with all the stresses that cause migraines in the first place. Mark Canadic Holistic Health Practitioner. Mark Canadic is a writer, speaker, holistic health practitioner and migraine community leader. Your email address will not be published. Save my name, email, and website in this browser for the next time I comment.
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Excedrin Migraine Pain Relief
Excedrin Migraine, is a combination of a non-steroid anti-inflammatory (aspirin), The same combination is in other OTC migraine medications such as Goody's Migraine Relief or Equate Hea The only difference between Excedrin extra strength and Excedrin migraine is the word Does marijuana cure migraine?. Platelets of women with migraine showed increased activity of FAAH when compared with men with migraine. Cupini et al. Cannabinoid compounds may stabilize and inhibit 5HT. Prescription drugs or over-the-counter, what's the difference? Acetaminophen plus caffeine, APAP and Aspirin, sold under the brand name Excedrin Migraine.