Name a sleep aid and I can describe the specific type of hangover it gives me. The morning after overdoing melatonin by even five milligrams. The FDA has approved the first marijuana drug, and cannabidiol may get Thousands of CBD products—oils, tinctures, vaporization liquids, The other news relates to the Senate's passage of the Farm Bill. help clarify the uncertain legal status of CBD that comes from hemp. .. Member Support. Update 09/29/18 – If you are considering a CBD based sleep aid, I've just released my In the mids, scientists identified the first cannabinoid. . Retrieved from: rodance.info . a cookie will be setup in your browser to remember this choice for one year.
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This tends to go entirely unheeded. One recent meme tells a wondrous tale of a man who cured his cancer with cannabis oil. This has been shared widely by cannabis enthusiasts, seemingly unaware that the man named in fact succumbed to his cancer months before.
It is common for such miraculous anecdotes to be shared and hailed as proof with little concern about their veracity.
Another frequent claim is that high-dose THC can kill cancer cells in a petri dish, which is true — but irrelevant. The astute reader will note that humans are not petri dishes, and killing cells can be achieved by many other agents, from heat to acid to bleach.
Killing cells is easy — an effective anti-cancer agent has to discriminately target cancer cells while sparing healthy ones, and there is no evidence that cannabis can do anything of the sort. This is damaging for several reasons. For one, it fosters a mistrust of the medical and scientific community. To preserve their faith, true believers dismiss the lack of evidence for their position as the machinations of Big Pharma. This casts researchers and medics as pantomime villains and makes them targets of abuse as I can attest.
Worse than that, the message is delivered so fervently that it persuades many patients to cease their conventional therapies. This has, and will, cost lives. Cannabis advocates are less keen to entertain the notion that it might have any adverse effects. As a general rule of thumb, anything that has a biological impact is likely to have some potential ill effect, and cannabis is no exception.
While relatively safe, regular users have an elevated chance of mental health disorders, including schizophrenia. For children and adolescents, these effects are much more pronounced, with negative implications for educational and social attainment. Contrary to popular misconception, addiction and problem usage are common , and more likely to manifest in heavy users and those who begin at a younger age.
None of this is to take away from the effectiveness of cannabis products for certain conditions, nor is it a discussion on legalisation. There may be good arguments for legalising cannabis — but exaggerating its potential use in medicine is not one of them.
If medicinal use is the true aim, then regulation of cannabis as a health product should not be controversial. The related mantra that cannabis is natural and ergo harmless is textbook naturalistic fallacy. Cyanide and plutonium are also naturally occurring, but unrestrained ingestion would be unwise. The reality is that most of the health claims made about cannabis are wrong-headed and devoid of evidence. They risk endangering the lives of the very patients they are supposed to help.
On Twitter he is drg After full adjustment, those who had used cannabis more than 50 times did not differ from never-users on either IQ or educational performance.
Adjusting for group differences in cigarette smoking dramatically attenuated the associations between cannabis use and both outcomes, and further analyses demonstrated robust associations between cigarette use and educational outcomes, even with cannabis users excluded.
These findings suggest that adolescent cannabis use is not associated with IQ or educational performance once adjustment is made for potential confounds, in particular adolescent cigarette use. C Mokrysz, et al. Published January 6, in Journal of Psychopharmacology. Health concerns regarding marijuana tend to come from a self-fueling group of discredited scientists funded by the pharmaceutical, prison, tobacco, and alcohol industries, pushing non-peer-reviewed papers while relying upon reports issued by others in their own group to further support their own grossly misleading research and clearly biased agendas.
The latest findings provide enough evidence for Dr. Schizophrenia affects approximately one percent of the population. Despite a massive increase in the number of Australians consuming the drug since the s, Wayne Hall of the University of Queensland found no increase in the number of cases of schizophrenia in Australia.
I think you are missing the main point. The article is not primarily about cannabis being a harmful, poisonous drug. It is much more harmful when it is peddled as a cure-all. This can lead to the more easily-suggestible in the population dumping a medicine that actually works for their condition, in favour of an ineffective drug someone on the internet told them was a miracle cure.
True, it may not achieve some of the overblown, snake oil claims but it will do no harm. It is less risky than eating peanuts. No one should ever discontinue conventional medical treatment if they choose to try cannabis.
Anyone who advises this is a foolish, irresponsible extremist, just as Dr Grimes has demonstrated that he is at the opposite extreme. Your attempt at discrediting the growing rediscovered medical cannabis industry will need to be improved to be taken seriously. Again due to research restrictions cannabis cannot be researched freely and openly in this country. But again we are limited at exploring the treatment further due to legal restrictions. Did you miss out on some funding for you south of France holiday home?
If you want the peer-reviewed stuff, click on the links in the article. I did find a study like this in Bonn though. Mice are not people. For someone who feels they are competent enough to criticise an experienced cancer-researcher, your criticism is sloppy and completely inaccurate.
Maybe it is something in the chemtrails. By mistake did you say!! No other alternative treatment since, so why not push for cannabis to researched more thoroughly — what is to loose i ask you?
Not once does any of the article reference the Endocannabinoid system — i wonder why? Is your Google broken? I do see one person saying that it is a bad idea to just make stuff up about cannabis and some others jumping on him as a blasphemer.
Which branch of the US government took out that patent, and when? What were its primary claims? Do you have a patent number for it? The fact remains that articles like these do not help the cause for access to medicinal cannabis for those who would benefit now, and with further research those who would benefit later. I for one welcome any potential treatments into dementia and the treatment of cancers such as Leukaemia having been closely affected by both. The people of the world have been lied to for too long.
Right, so there is a patent on a cannabis drug. How does that fit in with the usual claim that it is being suppressed because big pharma cant make money from it?
If it is patentable, then you can make money off it. How well does the drug work? This article is not intended to help people access cannabis now as far as I can see. It is intended to give people some facts about the actual real evidence that is available. The people of the world are being lied to by many of the proponents of cannabis treatments, including you earlier in this discussion.
This article addresses some of that disinformation. The people of the world are being lied to and have been for 80 years as too why cannabis is illegal. As stated before it remains extremely difficult for research to take place whilst something is illegal. I don;t know how they actually got a patent for just know one existed?
Well, what do you feel is the significance or relevance of that patent to this discussion then? Back in , the company Kannalife Sciences https: They have a target drug candidate, KLS https: Comparing cannabis with plutonium for any reason is more of a political stunt than a scientific analogy.
What a terrible, lazy, misguided, arrogant, stupid article. The author shows how very, very little he knows about this critical subject. The fact he says that cannabis has no efficacy for epilepsy shows his ignorance right there. As for cancer, cannabinoids in most cancer-related studies are shown to only kill cancer cells while sparing healthy ones. The science goes so much deeper than cannabis simply killing cancer cells. They do so through similar mechanisms as our own self-made endocannabinoids, and numerous studies with humans have shown these anti-cancer effects translate to us.
He also completely diminishes the overwhelming anecdotal evidence and the immense detail of it. You can read a summary of this evidence at http: That said, it is true that cannabis is not a cure-all and not everyone responds, whether it be cancer, epilepsy, or a number of other diseases.
The antitumour effects are modest at best and some of the preclinical studies found evidence that cannabinoids, under some circumstances, can actually stimulate cancer cell growth and contribute to tumour progression PMID: Furthermore, cancer cells can develop resistance PMID: The only human study that has been published to date was back in It was a cohort of nine patients all with recurrent glioblastoma multiforme PMID: All had their tumours resected and a catheter was placed in the cavity after surgery.
Then every day doctors would directly infuse a very pure THC solution at a high concentration directly into the cavity where the tumour had been, in the hope of killing off any remaining cancer cells. As for the two patients who survived the longest yet still died , the effects could be attributable to spontaneous but temporary regression of the disease PMID: You just commented on my post on another thread as well… do you purposely follow me around to counter what I say at every turn?
I do appreciate skepticism though, it is critical and none of these grandiose claims should be taken without serious inquiry. The bottom line is this is working though.
There are thousands of patients who have reported anticancer effects with cannabis, and I personally have watched three close family friends start-to-finish beat their cancers with cannabis oil. To say it is not working at this point is extremely dangerous because it takes away a real source of hope. And this at a remarkably low dose, FAR lower than what people are using to achieve remission. So we have massive scientific, anecdotal, and now clinical evidence this works.
The time for skepticism is over, we need to start saving patients. Read my book if you want to see how deep this goes on the human side. A 21 patient trial I am assuming you mean the GW Pharma one , has very low statistical value. It is a good sign, but it could just as easily be a statistical error.
The problem with this line of thinking is that people are dying of cancer every few seconds. They need treatments NOW, and waiting for years because people refuse to connect the dots results in millions of deaths. This trial is in the context of thousands of anecdotal cases of cannabis killing cancer. There is also other scientific evidence showing preclinical effects have translated to humans, such as the decrease of MMP-2 and VEGF shown in cells, animals, and humans.
Furthermore, other radical preclinical evidence, such as CBD for epilepsy, has translated to humans better than the preclinical evidence would suggest, since those studies use simple chemical-induced seizures vs.
THC kills cancer cells by activating CB1 receptors. Anandamide kills cancer cells by activating CB1 receptors. The evidence is absolutely enormous and this medicine must be made available now. I absolutely hate how people have no sense of urgency about this and refuse to think more deeply.
People should not forego conventional therapy and we still have a lot to learn. But there is absolutely no doubt cannabis has an anticancer effect in humans and it is time to take action on that knowledge.
If you think every single case in http: However I absolutely claim that in many cases cannabis extracts can directly treat cancer and can put cancers, even those terminally diagnosed, into remission, both alone and in conjunction with conventional treatment. Most people with cancer who use a significant dose of THC and CBD, at least mg total, see some kind of anticancer effect, even if it is simply slowing the rate of growth.
However some patients do not respond at all, even at exceptionally high doses reaching mg, which is why conventional therapy should never be foregone. The reason phytocannabinoids seem so effective against a wide range of cancers, despite the hundred of potential factors which can drive them, is because our endocannabinoid systems appear to have a role in preventing cancer cell proliferation. Ultimately, cancer is abnormal cells rapidly dividing, and there are some common mechanisms that drive these which cannabinoids can halt.
And for certain cancers with unique mechanisms of growth, cannabinoids often are effective against those. CBD has been shown to promote the differentiation of those cells which makes them more responsive to conventional treatment. This goes far deeper than a cannabinoid killing cancer in the same way bleach would.
Again, I urge you to look at the cases in my book. If you think every single one is a lie or a gross misinterpretation of the facts, all I can say is I disagree. Those cases are also a mere fraction of the reported anticancer successes, and they come from doctors, dispensaries, corporations, caregivers, from all over the world across a significant period of time. To think this is all coincidence and nothing is going on here, especially in the face of a placebo-controlled trial published three months ago and more emerging case reports in the literature, is absurd.
The trial was sponsored by GW Pharma who used their drug sativex a standardized whole plant oral mucosal spray. All this randomized study confirms is the treatment is generally well tolerated and the feasibility of individualized dosing when used as an adjunct to dose-intense temozolomide.
What GW should be doing is conducting a much larger Phase IIb trial using biomarkers to predict which patients will likely respond to the treatment and then going from there. The bottom line is this trial strongly confirms what is being seen in the real world.
Six months life extension is a big deal. While the trial was small, the chances their significantly extended survival was due to pure chance is absurd in the face of the massive scientific, anecdotal, and logical evidence.
You know, the chemical that when isolated and given to epileptic children, they stop having seizures that they would have previously had hundreds of times per week?
THC is one of just many cannabinoids, terpenes, and other molecules, which work together to provide different medical effects. Research on cannabis has a LONG way to go before you can make the broad, sweeping claims you do here. Their main criticism was the lack of control groups and placebos, even though many of the studies they cite show incredible results, for example Tzadok et al.
However, if you compare marijuana to the drugs that are commonly used to treat these conditions, the difference is staggering. The Epidiolex clinicals are quite interesting. They did show a clinically-significant improvement when compared to placebo, but they also showed a significant number of treatment-related serious adverse events. These serious adverse events increased with the concentration of CBD in the drug. While side-effects are to be expected with any drug, particularly one intended to treat a serious debilitating disease, these results do pour a bucket of cold water on the claims that CBD drugs have no harmful side-effects another myth promoted by the cannabis cult.
Why present the argument at all. The powers that be want pot in mass use, and, the marijuana growers have a lot of backing. Personally I have used marijuana with success to decrease the amount of grand mal epileptic seizures happening to me.
I did that about one year before I started on pharmaceuticals. I had no seizures after I started to smoke marijuana, though i was smoking hashish before that without the seizures going away. Marijuana does also help me with my anxiety, depression and sleep disorder.
It seems like not every strain helps equally much, hashish does work in some degree, but I wish I still had access to fine and cheap marijuana. Another thing that happened after I started smoking cannabis was strangely enough that I got cured from my asthma. A couple of weeks after I as a youth started to use cannabis in the weekends, my lung capacity drastically improved, and I no longer needed to use an inhalator. My chronic broncitus, which I got diagnosed with as a child, did not improve, however, I do not believe it got any worse either.
Also, I have supplied a senior citizen, a female, with marijuana because she had heard it could relieve her Chroms disease. And that it did. She actually managed to get outside for the first time in years because she could stop using several of the pharmaceuticals she had been taking.
I also gave marijuana to a cancer pation, and he finally got to eat and live without feeling nauseous all the time. I also gave cannabis to my alcoholic father with great success.
Cannabis did not cure any of these diseases, but it helped relieve them and made our lives better. Try the Mammoth strain. We are in this together.
Speaking of pharmacy drugs. I stopped taking them 4 years ago because they did absolutely nothing to stop my Grand Mals. In fact, they led to me having more seizures. I had 2 Grand Mals back to back and it royally fucked me up for about 6 months. Memory loss and speech loss for about the same amount of time. People suffering from a variety of conditions report that cannabis provides them with relief that no other drug provides.
As for recreational, what business is of yours what other adults choose to use? If so watch were you shove it or it might get cut off. Dr Grimes, if this really is your conclusion then you should be struck off for professional incompetence. Your assertions are absurd and fly in the face of the massive amount of high quality evidence which you seem determined to ignore.
Some reading for you. Being an idiot is hurting your life — try to adjust. You really do believe deep down that you have a panacea here for everything… which is what you would expect of a drug of this nature when it enmeshes with the human mind. The second link is a review of over 22, published and peer-reviewed studies by an internationally renowned neurologist. Nice Peter Reynolds with the save!! Thank you for your work.
The cat is out of the bag and there is no putting him back in. Try telling this to the thousands of people who have now been helped by cannabis.
Listen to what this retired judge, who has put hundreds away for marijuana has to say now that he has found the help of cannabis in reversing his COPD. It seems that when writing on the subject of medicine he should have made this clear. Instead he sought to endow his opinions with fake expertise.
It is true that there are many ridiculous snake oil claims made about cannabis curing cancer, although it would be foolish to write off all the anecdotal reports. They demonstrate an urgent need to advance research into the proven pre-clinical anti-cancer properties of cannabinoids. Most of these claims are made by people who are very sick, desperate or are relatives of people suffering from cancer.
Furthermore, the evidence is conclusive that cannabis offers great benefits as a palliative medicine for cancer and many other conditions. This is a summary of the evidence on cannabis and cancer which is balanced and warns of the snake oil claims but substantiates the proven benefits:. Your link is to a rather biased site. Want to appear credible, cite something impartial and with facts.
First your earlier attack on me after I calmly laid out my own case of being cured of cancer by using cannabis and now this rather weak-kneed attack on another intelligent commenter for his reasoned rebuttal to Dr. My advice to you? Get back to the adults in the room when you have something constructive to add to the conversation.
Ah and now your defending the racist homophobe because he shares your deluded views. Now your just looking like a stalker. Well, apply your stalking skills to googling Peter Reynolds and check out his various court cases. Obviously other sciences have a part to play in all sorts of medical research but Dr Grimes clearly knew that his title of doctor would endow his opinions with purported medical expertise. This is unethical and he should have made his qualifications clear and not allow readers to be misled.
Any doctor or scientist know that cancer is not one disease but has a myriad of different manifestations, and any one treatment that is claimed to be a cure all has to be suspicious. Also it takes years of in depth study to gain a PhD. Equally the author is simply stating that the evidence around cannabis curing cancer, as far as the evidence hierarchy goes, is not at the very top and that further research is needed before the gushing claims.
Furthermore, what exactly is unethical about the title Dr when used for a Dr of physics? You and Dr Grimes need to educate yourselves about the endocannabinoid system before you wade in clumsily demonstrating your ignorance. How we work out the difference between reproducible results of trials and those that may show promise and need further trials before they can have a place in medicine? Anecdotal evidence very low in the evidence hierarchy I agree , two words: Just to help you review your evidence: Oh and maybe educate yourself on this: Thus the MD was born.
Many PhDs are working extremely to hard to cure disease. Which has what relevance to the fact that in describing himself as a doctor and writing about medicine it is inevitable that readers will infer he is a medical doctor?
Oh and Peter, any chance you could present a coherent rebuttal and classify your evidence according to the evidence hierarchy rather than your childish ad hominem attacks.
Not like you to be nasty and mean is it, or to rampant sexism or stoop to homophobic and other attacks is it? Oh hang on, look what I found: I think any observer has only to look back at your comments to see very clearly who is behaving in childish fashion. A way to blame others for your own negative thoughts by repressing them and then attributing them to someone else.
Due to the sorrowful nature of delusion and denial it is very difficult for the target to be able to clarify the reality of the situation. Consult with your physician before using CBD if you are taking medication of any kind. Interactions with other supplements: CBD can increase sleepiness and drowsiness. When CBD is used in combination with other herbs or supplements that promote sleepiness, you may become excessively sleepy.
Some of the herbs and supplements used for sleep include: Rich in CBD, cannabis has been used for centuries to fight illness, improve sleep, and lower anxiety. Today, our understanding of the potential benefits of CBD is growing by leaps and bounds—more and more, CBD is seen as a powerful disease-fighting agent.
Alvarez, FJ et al. Neuroprotective effects of the nonpsychoactive cannabinoid in hypoxic-ischemic newborn piglets. Pediatric research, 64 6: Ashton, CH et al. Cannabinoids in bipolar affective disorder: Journal of psychopharmacology, 19 3: Bakas, T et al. Bradford, Alina , May Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free radical biology and medicine, 51 5: Boychuk, DG, et al. The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: Hypnotic and antiepileptic effects of cannabidiol.
Journal of clinical pharmacology, 21 Suppl: Chagas, MH et al. Journal of clinical pharmacy and therapeutics, 39 5: Cunha, JM et al. Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
Neural basis of anxiolytic effects of cannabidiol CBD in generalized social anxiety disorder: Journal of psychopharmacology, 25 1: Frontiers in Pharmacology, 7: Elikotil, J et al. The Analgesic Potential of Cannabinoids. Journal of Opioid Management, 5 6: Guindon, J and AG Hohmann. The endocannabinoid system and pain. Hampson, AJ et al.
Hsiao, Y-T et al. Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rates.
Hortes n Chagas, M et al. Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. Journal of Psychopharmacology, 27 3. Kwon, Diana , January Can Cannabis Treat Epileptic Seizures? Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. British Journal of Pharmacology, Cannabidiol enhances anadamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry, 2 3: Journal of Neuroendocrinology, Suppl 1: Mannucci, C et al.
Neurological aspects of medical use of cannabidiol. Journal of neurochemistry, 4: McAllister, SD et al. CBD may work on the body in a range of ways to help menopause symptoms. Of particular interest is the way that it interacts with cannabinoid receptors. The endocannabinoid system refers to a collection of cell receptors, called cannabinoid receptors, which are present in the brain, organs, and other tissues throughout the body.
Researchers believe that this system plays an essential role in many bodily functions and other aspects of health, including:. One theory is that a poorly functioning endocannabinoid system can lead to several different health conditions. Manipulating the chemicals involved in the system, such as CBD, could potentially help to treat such conditions. Menopause seems to disrupt the endocannabinoid system, and there are cannabinoid receptors throughout the female reproductive system, so it is possible that CBD oil could reduce some of the symptoms relating to menopause.
While there is no evidence indicating that CBD oil is likely to influence all menopause symptoms, it could be helpful for the following:. A study in mice found that CBD operates in a similar way to antidepressant medications in the brain, and reduces symptoms of depression. Being unable to sleep properly is a common complaint during menopause, and it can have a significant impact on daily life.
A case study on a person with post-traumatic stress disorder PTSD showed that CBD oil was able to reduce sleep disturbances and anxiety. It is possible that CBD oil may also be useful in treating the sleep disturbances relating to menopause. A low bone density can increase the chance of fractures or bruises, so it is an important symptom to treat. Some research has found that CBD interacts with a cannabinoid receptor that may play a role in bone density loss. CBD may, therefore, be able to reduce the rate of bone density loss that can occur during menopause.
At present, there is very little reliable evidence to suggest that CBD oil can treat the symptoms of menopause. Researchers have only just started to understand how the endocannabinoid system works and the role it may play in different health conditions. Future research in this area will be necessary to directly test theories relating to the role of CBD in menopause.
It will then be possible to determine whether or not CBD oil could help to reduce menopause symptoms. CBD is one of the active components found in hemp and marijuana. CBD has medicinal use but does not cause "high" associated with marijuana. Anyone who is considering using CBD for menopause or other health issues should research the legal use of CBD and other products in their area first. Article last reviewed by Mon 14 January Visit our Menopause category page for the latest news on this subject, or sign up to our newsletter to receive the latest updates on Menopause.
All references are available in the References tab. FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy. Where they are and what they do. Journal of Neuroendocrinology , 20 s1 , 10— Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids:
Cannabis health products are everywhere – but do they live up to the hype?
Cannabidiol is being touted as a magical elixir, a cure-all now told Coveteur that she was experimenting with CBD oil to relieve the pain from wearing high heels. a board member of Dosist, a cannabis company in Santa Monica, Calif., “You are inundated with terrible news, and you have no choice to. Cannabidiol, or CBD, is now available in the UK in everything from skin As well as ingestible CBD (also sold as hemp or cannabis oils or But although there's tons of stuff in the news about it, there's still not that much evidence. and support for healthy sleep cycles,” says co-founder Jesse Stanley. There are many potential benefits of using cannabis where the drug is legal. One of these is as a sleep aid. There are, however, things to be.