The potential anti-seizure, anti-inflammatory and anti-tumor properties of cannabidiol (CBD) are what get most of the attention, but not to be. It's a little known fact that applying CBD topicals is a great way to Also, we'll cover the basics like any potential benefits of applying CBD to. We looked into topical CBD benefits and how it could help with skin and joint Potential For Relief Of Arthritis': Science Examines Topical CBD.
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Histological analysis was conducted in the four experimental groups: Mean intensities were averaged and compared across treatment groups. GraphPad Prism version 6. Animals were treated with CBD gel in four different doses: After four consecutive days of treatment, plasma CBD concentrations in all rats were 3.
However, CBD plasma concentrations after application of the Daily applications of 6. Assessment of knee joint inflammation. A Ipsilateral knee joint circumference was significantly increased in rats with adjuvant-induced monoarthritis and significantly decreased after four consecutive days of transdermal cannabidiol CBD treatment using 6. B Pain scores median were maximal 3 days after adjuvant-induced monoarthritis and were significantly reduced by 6.
F Bar graph shows high doses of CBD combined 6. Transdermal application of 6. Limb posture scores as a rating of spontaneous pain were high on day 3 median score 4 in all animals with adjuvant-induced monoarthritis. On day 7, after 4 days of transcutaneous treatment with 6. Pain scores of animals that received 0. All naive rats scored 0 in this test. Baseline paw withdrawal latencies were similar in all experimental animals 10—12 s.
Hypersensitivity to noxious heat was detected in all animals with adjuvant-induced monoarthritis. Average paw withdrawal latency PWL in response to radiant heat applied to the plantar surface of the same side hindpaw, was significantly decreased on day 3 from After 2 days of treatment with 6. Reduction in monoarthritis-induced heat hypersensitivity was maximal after 2 days of transdermal application of 6.
Adjuvant-induced heat hypersensitivity was not changed by transdermal application of vehicle, nor by 0. Daily application of CBD gel on naive animals did not alter heat sensitivity irrespective of the concentration used Fig. Transdermal cannabidiol CBD reduced monoarthritis-induced hind paw heat hypersensitivity. C, D In the open-field test, transdermal CBD exerts no detectable effect on times spent in spontaneous exploratory activity or resting.
Potential for adverse side-effects on activity levels or motor abilities stemming from CBD gel application were assessed by monitoring open-field exploratory behaviour of naive animals for 45 min prior to and directly after treatment. Irrespective of the amount of CBD applied onto the back of animals, no changes were detected for total time spent in either exploratory activity or resting Fig.
Two other specific exploratory activities acquired in the open-field test but not affected by CBD were rearing events in which the animals rise on their hindlimbs to explore the environment and the total distance travelled during the 45 min test data not shown.
After batch staining immunohistochemical methods, the intensity of immunofluorescence was determined using computer assisted quantification. The immunoreactivity for neuropeptide CGRP was significantly increased in the superficial dorsal horn of the spinal cord in the monoarthritis group.
Treatment with high doses of CBD 6. Immunocytochemical localization of inflammatory biomarkers. Quantification of pro-inflammatory biomarkers in the lumbar spinal cord and dorsal root ganglia DRG. Naive animals had low levels of OX42 expression in the spinal cord, a marker for activated microglia Fig.
Outcomes of this study indicate that topical application of CBD gel is an effective treatment for reduction in inflammation and hypersensitivity associated with the rodent adjuvant-induced monoarthritis model. Transdermal administration of CBD provided good blood absorption due to avoidance of first pass metabolism encountered by orally administered drugs. Similarly in this study, CBD plasma concentrations for rats dosed with 0.
However, the highest dose, The lack of increased outcome for this highest CBD concentration was potentially due to maximally activated CBD effects or capacity-limit absorption and metabolism. This would account for the flattened linear pharmacokinetic profile effect of the Spreading large quantities of gel directly on the skin over the joint itself was not feasible in this transdermal dosing paradigm and would provide opportunity for oral ingestion by the rats.
Efficacy of transdermal CBD for reduction in inflammation-associated symptoms in adjuvant-induced monoarthritic animals was determined comparing knee joint circumference and other features. Likewise, increased synovial membrane thickness was reduced by the 6. These results concur with previous studies showing orally administered CBD decreased inflammation Malfait et al.
Decreased inflammation and reduction in secretions of pro-inflammatory and matrix-degrading effector molecules by the synovial cell connective tissue membrane lining the joints are important for symptomatic treatment of patients with rheumatoid arthritis. Pro-inflammatory and matrix-degrading effector molecules produced in excess are primary contributors to cartilage degradation over time Ospelt et al. The improvement of pain scores provided by transdermal CBD is an indirect measure of joint inflammation and direct measure of function.
The PWL in response to noxious heat stimuli was optimal with both the 6. Analogous to the results presented here, the highest dose of CBD administered in that study also did not perform as well as the next lower dose. In the same study at 6 h post inflammation, CBD treatment with two orally administered lower doses, 5 and 7. Peripheral inflammation and hypersensitivity are reversed by pharmacological inactivation of both central and peripheral neurons and central microglia Sluka et al. Although CBD is described as an attenuator of both mechanical and heat hypersensitivity induced by inflammatory and neuropathic pain models, the exact mechanism of action is as yet unknown Mechoulam and Hanus, ; Kress and Kuner, Unlike THC and related cannabinoids, phytocannabinoid-CBD, an important bioactive component of Cannabis sativa without psychotropic effect, is an antagonist of orphan G protein-coupled receptor 55 GPR55, a potential third metabotropic cannabinoid receptor without binding to CB1 and CB2 receptors Begg et al.
A particular focus has been on TRPA1 and TRPV1, two widely co-expressed ion channels found in CGRP expressing peptidergic nociceptors essential for neurogenic inflammation, oedema formation and inflammation-induced mechanical and thermal hypersensitivity Davis et al. Their activation by CBD in vitro results in desensitized responses following noxious stimulation with capsaicin or mustard oil, their respective agonists.
This mechanism potentially decreases neuropeptide expression Bisogno et al. In vivo absence or inhibition of TRPA1 results in reduced mechanical hypersensitivity in animal models of inflammation Petrus et al. Absence of TRPV1 in vivo reduces inflammation-induced swelling, thermal hypersensitivity and nociceptive behaviour in various pain models Caterina et al.
In naive animals, TRPV1 immunoreactivity is localized in nociceptive primary afferents innervating the knee joint. After inflammation, TRPV1 expression increases not only in primary afferents, but is detected in synoviocytes which secrete lubricating fluid into the synovial space and function as local immune cells Kochukov et al. Primary afferents are thus not only sensitized by peripheral release of pro-inflammatory cytokines, but are surrounded by cells that produce and release these molecules themselves.
Further studies are needed to identify specific receptors and mechanisms underlying the anti-inflammatory and anti-hyperalgesic effects of CBD. Transdermal CBD application was successful in decreasing monoarthritis-associated increases of pro-inflammatory biomarkers in neuronal tissues. In this study, the expression of CGRP in spinal cord was increased after peripheral inflammation as previously reported Sluka and Westlund, , and was decreased by high doses 6.
Like other neuropeptides, CGRP is rapidly transported to nerve terminals for release centrally as well as peripherally where as a potent vasodilator it contributes to neurogenic inflammation Kawasaki et al. Although increases in CGRP are described in DRG after hindpaw inflammation Nahin and Byers, , no significant changes in DRG expression were observed here data not shown , possibly due to the small number of sensory neurons innervating the joint. It is also plausible that by 7 days post monoarthritis induction, neuropeptide content has stabilized.
In monoarthritic animals, spinal cord OX42 expression is increased in activated microglia, the immune cells specific to the central nervous system, as previously described for CFA-induced ankle inflammation and trinitrobenzene sulfonic acid TNBS -induced pancreatitis Shan et al.
Treatment with high doses of transdermal CBD in this study effectively reduced OX42 expression below baseline levels, indicating reduced microglial activation. CBD is a known non-psychoactive cannabinoid, and due to its low affinity for the CB1 receptor it would be expected that exploratory behavioural activity would be similar among treatment groups compared to negative side-effects associated with THC Croxford, ; Malone et al.
This was demonstrated in this study by lack of CBD-induced changes in open-field exploration among naive treatment groups. Combinatorial with psychoactivity, side-effects such as hypothermia and hypomobility induced by THC are avoided with use of CBD Zimmer et al. These studies demonstrate transdermal administration of CBD has long-lasting therapeutic effects without psychoactive side-effects.
Thus, use of topical CBD has potential as effective treatment of arthritic symptomatology. If your skin symptoms have appeared suddenly or if they are very strong and painful, you should first consult your physician before using any supplements or salves.
Don't use salves on open, bleeding wounds. Also, do not apply CBD topicals if you are pregnant, lactating, or suffering from a serious illness. Please keep your CBD topicals stored in a cool, dry place, well out of the reach of children and pets. Our mission here at Healthy Hemp Oil is to become the most consumer-focused provider of CBD topicals available online.
This attention to detail extends to our carefully curated selection of CBD topical products. Browse our range of CBD salves, ointments, and other topicals, or get in touch if you have any questions.
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Rest assured, we are working to get packages out as quickly as possible. Studies have named cannabidiol as an effective treatment for IBS because of its ability to control the neuroimmune system, a network of structures connecting the gut microbes, immune system, and central nervous system. Researchers have discovered CBD could potentially be used as a topical therapy to treat glaucoma. CBD and other cannabinoids have been shown to protect neuron cultures from glutamate-induced death.
In recent years, medical researchers have become increasingly interested in CBD as a treatment for seizures and epilepsy, particularly for children.
CBD contains anticonvulsant properties like other cannabinoids, in addition to the advantage of being non-psychoactive. Thanks to its anti-inflammatory properties , cannabidiol has been introduced to lotions and other skincare products to treat acne. CBD has been demonstrated to help ease pain and inflammation in a variety of chronic pain diseases, including arthritis and multiple sclerosis.
One of the most intriguing properties of cannabidiol is its ability to promote restful sleep. CBD has been used for centuries across many cultures as a sleep aid. Mounting evidence shows that cannabidiol may be able to help reduce anxiety symptoms. CBD may be a powerful treatment for a variety of forms of anxiety, including social anxiety, obsessive-compulsive disorder, and post-traumatic stress disorder. Abnormalities in the endocannabinoid system have been linked to depression and suicide.
Research finds that CBD oil can help increase and stabilize the release of serotonin, a natural mood regulator. Studies find that the endocannabinoid system may be an ideal avenue for treating post-traumatic stress disorder PTSD. Scientific findings link the endocannabinoid system to the regulation of stress and other emotional behaviors. While many of the potential benefits of CBD oil have been observed in animals, a limited number of studies have been performed with humans.
There is also a lack of data regarding how CBD may affect children or long-term users after several decades. Although research shows CBD has a relatively low toxicity, not all potential interactions have been studied.
Lack of regulation means CBD products may vary widely in quality, labeling, purity, and reliability. Interactions with other pharmaceuticals.
Studies suggest that CBD oil may interact adversely with certain drugs. CBD and other cannabinoids can inhibit the liver enzyme P, which metabolizes many medications. At certain doses, CBD could impact the metabolization of pharmaceuticals like anti-epileptics, steroids, and antihistamines. As with other cannabinoids , there have been no reported fatal overdose levels of CBD oil. Studies show that patients can tolerate quite high doses of cannabidiol. That said, high doses of CBD may increase severity of side effects such as drowsiness and nausea, and an excessive dose of CBD oil may be less effective than a moderate amount.
Changes in weight and appetite. Like other cannabinoids, CBD oil may induce feelings of hunger. An increased appetite can lead to a change in eating patterns, which in turn can result in weight gain. A natural sleep remedy, CBD oil may incite feelings of drowsiness. Feelings of tiredness could last for two to six hours, depending on the method of consumption. CBD oil may cause a minor drop in blood pressure, resulting in an initial feeling of dizziness or lightheadedness.
Diarrhea has been reported as a side effect accompanying high levels of CBD oil. To avoid diarrhea, users are advised to lower their dosage. This condition may lead to feelings of thirst and mild discomfort. How to take CBD Oil.
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You've probably heard that cannabis topicals are great for your skin, but did you So you can apply them liberally without the potential side effects of too much THC. One study found that Cannabidiol (CBD) is a more potent. CBD topicals can be an effective treatment for many symptoms. Due to its wide variety of medical benefits, CBD is used to treat a 1 Massi P, Solinas M, Cinquina V, Parolaro D. Cannabidiol as potential anticancer drug. Scientists studying the health benefits of CBD have found it is a promising natural to consume more calories per day, an activity that is potentially related to THC's .  Cannabis-based topical products are being developed to treat related.