Another cornerstone in cannabinoid research was the identification of the specific binding sites of dTHC in the. The Cannabis plant produces hundreds of different cannabinoids and over four hundred complex-compounds that make up the plant anatomy. Cannabis produces a variety compounds known as cannabinoids, many of which have not been detected in any other plant. How many, exactly? It's hard to say.
(the compounds in plants) Cannabinoids cannabis
THC binds primarily to CB1 receptors, thus producing effects similar to that of anandamide. This makes dosing THC a bit tricky and is usually subjective. You may have noticed this yourself—take two complete cannabis rookies and you will see that one needs just a few puffs to get high while another might need more to get the same results.
Another point to consider is the biphasic nature of THC, meaning that adequate stimulation of these receptors may produce one effect, while overstimulation may produce a completely opposite effect. THC has also been shown to relieve symptoms of conditions such as insomnia , chronic pain , arthritis , migraines , and it even helps us forget traumatic memories that cause PTSD.
Cannabidiol, or just CBD for short, is a rising star in the cannabis world. CBD is the second most prevalent cannabinoid in the plant, although in recent years cultivators have managed to create new high CBD strains by cross-breeding plants with different genetics.
Mechoulam in the s , which means that the modern science has had its hands on it for quite some time. There are tons of studies on CBD and its medical effects and we can confidently say that it reduces seizure frequency in epilepsy patients, relieves inflammation, and reduces anxiety and neuropathic pain.
Download a free dosage guide that will show you the exact step-by-step process Dr. Dustin Sulak used to successfully treat more than 18, patients with cannabis. CBG has some very promising medical potential as this cannabinoid has shown to be very effective in lowering ocular pressure. Also, it works as an antibacterial agent, appetite stimulant and muscle spasm inhibitor.
It has also shown some promising cancer-fighting properties by blocking the growth of cancer cells. Cannabinol is the most sedative cannabinoid of all, producing the couch-lock effect in conjunction with THC and a terpene called myrcene. That usually happens when the buds are stored for too long. Although this is a less researched cannabinoid, early findings suggest that it has great potential, especially in combination with other cannabinoids.
Besides its sedative effect and its use as a sleeping aid, this cannabinoid when used alongside CBD and CBG is an effective treatment for psoriasis, by decreasing the proliferation of keratinocytes. Early research has shown that CBN instigates the growth of stem cells in the bone marrow, helping the bones to form and grow. Cannabichromene is another non-intoxicating cannabinoid, which has a low binding affinity for CB1 receptors, but it has more affinity towards other receptors in our body that are connected with pain regulation.
Although CBC has a lot of potential on its own, it seems that it works best in synergy with other cannabinoids, in the so-called the entourage effect, helping other cannabinoids reach their full potential. A study by the Italian Institute of Biomolecular Chemistry suggests that CBC may boost neurogenesis the production of neurons in stem cells by improving their function.
In one animal study, rats who were treated with CBC performed better in stressful situations. Besides its antifungal and antibacterial effects, a recent study suggested that this cannabinoid may perform better than other medications used for treating the MRSA virus. Unlike THC, it suppresses the appetite. THCV is of interest to diabetics as one study found that it regulates blood sugar and insulin levels. Along with other cannabinoids, it reduces panic attacks caused by anxiety or PTSD, and there are some indications that it stimulates bone growth as well.
A few studies confirmed that CBDV helps in reducing epileptic seizures, and there is evidence of its ability to relieve nausea. Cannabicyclol is another non-psychoactive phytocannabinoid but still not studied or understood nearly enough.
Instead, most of the research done so far has focused on its chemical structure. Cannabivarin is another compound in the cannabis plant that is derived from THC but does not make people high. Another lesser-known cannabinoid, CBCV does not produce mind-altering effects. It was discovered back in when Japanese researchers isolated it for the first time from the cannabis plant. There is still a lot of research to be done on this cannabinoid, but because of its similarity with CBC, medical experts speculate that it acts as a painkiller and antidepressant.
Researchers from the University of Ohio discovered cannabielsoin back in , and this cannabinoid is classified as a metabolite of CBD. Cannabitriol has the same structure as THC, but it has two more alcohol groups added.
It was discovered, isolated and described in by Yataro Obata and Yoshinori Ishikawa. Early research has shown that it has some promising properties: First of all, it seems to be a great appetite stimulant, by some accounts boosting appetite even better than THC. Back in , delta 8 -THC was introduced into nausea therapy for children with cancer between the ages of 2 and It was surprising to see how well the children responded to treatment, with no reported psychoactive effects.
Synthetic cannabinoids entered the market in the early s in an attempt to avoid legal restrictions that follow cannabis around the world. They are, of course, made artificially to bind to the same receptors as phytocannabinoids and endocannabinoids, however, they are much more potent and dangerous. The problem with this is that synthetic cannabinoids can be life-threatening and there are a number of deaths associated with them.
Pharmaceutical companies have designed artificial cannabinoids to treat nausea, vomiting, loss of appetite and, most recently, epilepsy. These are not to be mistaken with black market synthetic cannabinoids such as K2 and Spice. There are more than a hundred cannabinoids in the plant, but only a few are intoxicating and even fewer have been thoroughly researched. Cannabinoids play a very important role in the evolution of cannabis, protecting the plant while benefiting our endocannabinoid system as well.
The more we learn about cannabis, the more it looks like a half-explored mine of medical benefits, however, we must never forget the fact that cannabinoids work best when combined. Only then can they play off each other and, with the help of terpenes, produce a multitude of medical benefits. Journalist with a decade-long experience of using cannabis for stress relief. Her spare time is mostly divided between dancing, traveling and reading.
Most of that which has been written I have known since when I joined what was known then as The Marywana Research Foundation in Melb. This covered a lot more that was unknown in those days so thanks for bringing us up to date. Up-to-date research indicates that cannabis may be an appropriate treatment of patients suffering from chronic pain and associated symptoms. These symptoms include flashbacks, nightmares, night-sweats, avoidance of painful stimuli, anxiety, insomnia and others.
It is one of the few conditions that can be pinpointed to have begun with a traumatic event or experience. PTSD is a complex condition which often involves a multi-faceted approach to symptom management. In addition to psychotherapy and traditional pharmacological therapy, many patients report positive outcomes with non-conventional therapies such as medical cannabis.
Research indicates that the endocannabinoid system plays an important role in PTSD symptom management. A study by Greer et al. Similarly, research on animals suggests that cannabis has a great potential to provide anxiety reducing effects. These anxiolytic effects are due to the abundance of CB1 receptors in the part of the brain used to process fear, anxiety and emotional learning. The endocannabinoid system also plays an important role in the regulation of aversive memories in patients with PTSD.
Marsicano and colleagues conducted an experiment in which CB1 receptors were deleted or significantly reduced in mice, and compared their abilities to acquire fearful memories and to overcome those same memories.
Without the CB1 receptors, mice had greater difficulty overcoming fearful memories, but had no problem acquiring them. This suggests that the endocannabinoid system may play a key role in the regulation of emotional responses.
Clinical trials using synthetic THC echo the findings that cannabinoids have the potential to help patients suffering from PTSD work through the fear associated with their memories.
A study conducted by Rabinak et al. The study concluded that individuals who received synthetic THC had heightened brain activity in areas associated with overcoming fearful memories. Often called marijuana, cannabis refers to the cannabis sativa plant. Cannabis sativa is a species of plant composed of several complex compounds, with the most notable compounds being Tetrahydrocannabinol THC and Cannabidiol CBD. It is legal to use cannabis for medical purposes in Canada, provided you: Licensed Producers are regulated by Health Canada and follow strict quality control guidelines.
Once your doctor authorizes medical cannabis by completing a Medical Document, you are required to select and register with a Licensed Producer, and place an order directly with that producer. Licensed Producers offer different strains of medical cannabis at different prices. Patients typically choose the Licensed Producer based on strain availability and medication cost.
The Medical Document prescription you receive from your physician can only be sent to one Licensed Producer. There are different ways to consume medical cannabis, including vaporizing, and consuming oils and other derivative products. GrowWise can assist you in finding the mode of consumption that would work best for you. The therapeutic effects of cannabis vary according to the content and ratio of THC and CBD compounds of the specific strain type.
A GrowWise Patient Educator can assist you in choosing the strain best suited to help you manage your symptoms and condition. For Patients Have a Prescription? Is Medical Cannabis Right for You? Medical Cannabis for Chronic Pain. Eur J Pain Lynch ME, Campbell F Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized controlled trials. Br J Clin Pharmacol Cannabis and Post Traumatic Stress Disorder.
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Understand Medical Cannabis
Cannabis contains a variety of different compounds called THC is also commonly extracted from the plant and used in a variety of methods. With a rising demand for natural medicines, cannabis compounds, There are currently 85 known cannabinoids found in the Cannabis plant. The most common and prevalent of these compounds, THC, produces that To increase these ratios and purify CBD, flowers are frequently.